Bone Abstracts

As a bone-derived hormone that regulates phosphate homeostasis and renal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production, fibroblast growth factor (FGF)-23 has been postulated to indirectly control calcium and bone metabolism by modulating the levels of phosphate and 1,25(OH)2D3. However, the presence of FGF receptor-1 (FGFR-1) proteins in the intestinal epithelial cells suggests that the intestine may directly respond t...

A decrease or absence of beta-globin production in erythroid cells causes a hereditary anemic disorder known as beta-thalassemia, which is associated with ineffective erythropoiesis, iron overload, growth retardation, osteopenia, and osteoporosis. Our recent investigation revealed that beta-thalassemia led to osteoclast-mediated bone resorption and the impaired intestinal calcium absorption, the latter of which modestly responded to conventional 1,25-dihydroxyvitamin D3</...